PSENEN DNAxPab
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Specification
Product Description
Rabbit polyclonal antibody raised against a full-length human PSENEN DNA using DNAx™ Immune technology.
Technology
Immunogen
Full-length human DNA
Sequence
MNLERVSNEEKLNLCRKYYLGGFAFLPFLWLVNIFWFFREAFLVPAYTEQSQIKGYVWRSAVGFLFWVIVLTSWITIFQIYRPRWGALGDYLSFTIPLGTP
Host
Rabbit
Reactivity
Human
Purification
Protein A
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Transfected lysate)
Immunofluorescence (Transfected cell)
Flow Cytometry (Transfected cell)
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Gene Info — PSENEN
Entrez GeneID
55851GeneBank Accession#
NM_172341.1Protein Accession#
NP_758844.1Gene Name
PSENEN
Gene Alias
MDS033, MSTP064, PEN-2, PEN2
Gene Description
presenilin enhancer 2 homolog (C. elegans)
Omim ID
607632Gene Ontology
HyperlinkGene Summary
Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase. [provided by RefSeq
Other Designations
hematopoietic stem/progenitor cells protein MDS033|presenilin enhancer 2
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Interactome
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Pathway
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Disease
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