Immunoprecipitation of CENPJ transfected lysate using anti-CENPJ MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead (U0007), and immunoblotted with CENPJ purified MaxPab mouse polyclonal antibody (B01P) (H00055835-B01P).
This gene encodes a protein that belongs to the centromere protein family. During cell division, this protein plays a structural role in the maintenance of centrosome integrity and normal spindle morphology, and it is involved in microtubule disassembly at the centrosome. This protein can function as a transcriptional coactivator in the Stat5 signaling pathway, and also as a coactivator of NF-kappaB-mediated transcription, likely via its interaction with the coactivator p300/CREB-binding protein. Mutations in this gene are associated with primary autosomal recessive microcephaly, a disorder characterized by severely reduced brain size and mental retardation. [provided by RefSeq
LAG-3-associated protein,LYST-interacting protein LIP1,LYST-interacting protein LIP7,OTTHUMP00000018137,centrosomal P4.1-associated protein