Immunoprecipitation of SELS transfected lysate using anti-SELS MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead (U0007), and immunoblotted with SELS purified MaxPab mouse polyclonal antibody (B02P) (H00055829-B02P).
This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Studies suggest that this protein may regulate cytokine production, and thus play a key role in the control of the inflammatory response. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq