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TDP1 293T Cell Transient Overexpression Lysate(Denatured)

  • Catalog # : H00055775-T01
  • Visit Frequency :
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  • Specification
  • Transfected Cell Line:
  • 293T
  • Plasmid:
  • pCMV-TDP1 full-length
  • Host:
  • Human
  • Theoretical MW (kDa):
  • 66.99
  • Quality Control Testing:
  • Transient overexpression cell lysate was tested with Anti-TDP1 antibody (H00055775-B01) by Western Blots.
    SDS-PAGE Gel
    QC Testing of H00055775-T01
    TDP1 transfected lysate.
    Western Blot
    QC Testing of H00055775-T01
    Lane 1: TDP1 transfected lysate ( 68.4 KDa)
    Lane 2: Non-transfected lysate.
  • Storage Buffer:
  • 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
  • Storage Instruction:
  • Store at -80°C. Aliquot to avoid repeated freezing and thawing.
  • Applications
  • Western Blot
  • Application Image
  • Western Blot
  • Gene Information
  • Gene Name:
  • TDP1
  • Gene Alias:
  • FLJ11090,MGC104252
  • Gene Description:
  • tyrosyl-DNA phosphodiesterase 1
  • Gene Summary:
  • The protein encoded by this gene is involved in repairing stalled topoisomerase I-DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of topoisomerase I and the 3-prime phosphate of DNA. This protein may also remove glycolate from single-stranded DNA containing 3-prime phosphoglycolate, suggesting a role in repair of free-radical mediated DNA double-strand breaks. This gene is a member of the phospholipase D family and contains two PLD phosphodiesterase domains. Mutations in this gene are associated with the disease spinocerebellar ataxia with axonal neuropathy (SCAN1). While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform. [provided by RefSeq
  • Other Designations:
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