C20orf31 monoclonal antibody (M01), clone 2E4
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More Files
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Specification
Product Description
Mouse monoclonal antibody raised against a partial recombinant C20orf31.
Immunogen
C20orf31 (NP_060687, 479 a.a. ~ 578 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
PIDPAALHCCQRLKEEQWEVEDLMREFYSLKRCRSKFQKNTVSSGPWEPPARPGTLFSPENHDQARERKPAKQKVPLLSCPSQPFTSKLALLGQVFLDSS
Host
Mouse
Reactivity
Human
Isotype
IgG1 Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (36.74 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Transfected lysate)
Western Blot analysis of EDEM2 expression in transfected 293T cell line by C20orf31 monoclonal antibody (M01), clone 2E4.
Lane 1: EDEM2 transfected lysate(64.8 KDa).
Lane 2: Non-transfected lysate.
Western Blot (Recombinant protein)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunoperoxidase of monoclonal antibody to C20orf31 on formalin-fixed paraffin-embedded human stomach. [antibody concentration 1.5 ug/ml]Immunoprecipitation
Immunoprecipitation of EDEM2 transfected lysate using anti-EDEM2 monoclonal antibody and Protein A Magnetic Bead, and immunoblotted with EDEM2 MaxPab rabbit polyclonal antibody.Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged EDEM2 is 0.1 ng/ml as a capture antibody.ELISA
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Gene Info — EDEM2
Entrez GeneID
55741GeneBank Accession#
NM_018217Protein Accession#
NP_060687Gene Name
EDEM2
Gene Alias
C20orf31, C20orf49, FLJ10783, bA4204.1
Gene Description
ER degradation enhancer, mannosidase alpha-like 2
Omim ID
610302Gene Ontology
HyperlinkGene Summary
In the endoplasmic reticulum (ER), misfolded proteins are retrotranslocated to the cytosol and degraded by the proteasome in a process known as ER-associated degradation (ERAD). EDEM2 belongs to a family of proteins involved in ERAD of glycoproteins (Mast et al., 2005 [PubMed 15537790]).[supplied by OMIM
Other Designations
ER degradation-enhancing-mannosidase-like protein 2|OTTHUMP00000030728
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