Immunoprecipitation of NLRP2 transfected lysate using anti-NLRP2 MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead (U0007), and immunoblotted with NLRP2 purified MaxPab mouse polyclonal antibody (B01P) (H00055655-B01P).
NALP proteins, such as NALP2, are characterized by an N-terminal pyrin (MIM 608107) domain (PYD) and are involved in the activation of caspase-1 (CASP1; MIM 147678) by Toll-like receptors (see TLR4; MIM 603030). They may also be involved in protein complexes that activate proinflammatory caspases (Tschopp et al., 2003 [PubMed 12563287]).[supplied by OMIM
NACHT, LRR and PYD containing protein 2,NACHT, leucine rich repeat and PYD containing 2,PYRIN-Containing APAF1-like,nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 2