OTUB1 (Human) Recombinant Protein (P01)
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More Files
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Specification
Product Description
Human OTUB1 full-length ORF ( AAH07519, 1 a.a. - 271 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MAAEEPQQQKQEPLGSDSEGVNCLAYDEANMAQQDRIQQEIAVQNPLVSERLELSVLYKEYAEDDNIYQQKIKDLHKKYSYIRKTRPDGNCFYRAFGFSHLEALLDDSKELQRFKAVSAKSKEDLVSQGFTEFTIEDFHNTFMDLIEQVEKQTSVADLLASFNDQSTSDYLVVYLRLLTSGYLQRESKFFEHFIEGGRTVKEFCQQEVEPMCKESDHIHIIALAQALSVSIQVEYMDRGEGGTTNPHIFPEGSEPKVYLLYRPGHYDILYK
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
55.55
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — OTUB1
Entrez GeneID
55611GeneBank Accession#
BC007519Protein Accession#
AAH07519Gene Name
OTUB1
Gene Alias
FLJ20113, FLJ40710, HSPC263, MGC111158, MGC4584, OTB1, OTU1
Gene Description
OTU domain, ubiquitin aldehyde binding 1
Omim ID
608337Gene Ontology
HyperlinkGene Summary
The product of this gene is a member of the OTU (ovarian tumor) superfamily of predicted cysteine proteases. The encoded protein is a highly specific ubiquitin iso-peptidase, and cleaves ubiquitin from branched poly-ubiquitin chains but not from ubiquitinated substrates. It interacts with another ubiquitin protease and an E3 ubiquitin ligase that inhibits cytokine gene transcription in the immune system. It is proposed to function in specific ubiquitin-dependent pathways, possibly by providing an editing function for polyubiquitin chain growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq
Other Designations
OTU-domain Ubal-binding 1|otubain 1|ubiquitin-specific protease otubain 1
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