OTUB1 monoclonal antibody (M09), clone 1C12
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More Files
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Western Blot (Cell lysate)
OTUB1 monoclonal antibody (M09), clone 1C12. Western Blot analysis of OTUB1 expression in Hela S3 NE ( Cat # L013V3 ).
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged OTUB1 is 1 ng/ml as a capture antibody.
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Specification
Product Description
Mouse monoclonal antibody raised against a full-length recombinant OTUB1.
Immunogen
OTUB1 (AAH07519, 1 a.a. ~ 271 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
MAAEEPQQQKQEPLGSDSEGVNCLAYDEANMAQQDRIQQEIAVQNPLVSERLELSVLYKEYAEDDNIYQQKIKDLHKKYSYIRKTRPDGNCFYRAFGFSHLEALLDDSKELQRFKAVSAKSKEDLVSQGFTEFTIEDFHNTFMDLIEQVEKQTSVADLLASFNDQSTSDYLVVYLRLLTSGYLQRESKFFEHFIEGGRTVKEFCQQEVEPMCKESDHIHIIALAQALSVSIQVEYMDRGEGGTTNPHIFPEGSEPKVYLLYRPGHYDILYK
Host
Mouse
Reactivity
Human
Isotype
IgG2a Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Cell lysate)
OTUB1 monoclonal antibody (M09), clone 1C12. Western Blot analysis of OTUB1 expression in Hela S3 NE ( Cat # L013V3 ).Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged OTUB1 is 1 ng/ml as a capture antibody.ELISA
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Gene Info — OTUB1
Entrez GeneID
55611GeneBank Accession#
BC007519Protein Accession#
AAH07519Gene Name
OTUB1
Gene Alias
FLJ20113, FLJ40710, HSPC263, MGC111158, MGC4584, OTB1, OTU1
Gene Description
OTU domain, ubiquitin aldehyde binding 1
Omim ID
608337Gene Ontology
HyperlinkGene Summary
The product of this gene is a member of the OTU (ovarian tumor) superfamily of predicted cysteine proteases. The encoded protein is a highly specific ubiquitin iso-peptidase, and cleaves ubiquitin from branched poly-ubiquitin chains but not from ubiquitinated substrates. It interacts with another ubiquitin protease and an E3 ubiquitin ligase that inhibits cytokine gene transcription in the immune system. It is proposed to function in specific ubiquitin-dependent pathways, possibly by providing an editing function for polyubiquitin chain growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq
Other Designations
OTU-domain Ubal-binding 1|otubain 1|ubiquitin-specific protease otubain 1
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Interactome
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Publication Reference
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Post-translational modification of the deubiquitinating enzyme otubain 1 modulates active RhoA levels and susceptibility to Yersinia invasion.
Edelmann MJ, Kramer HB, Altun M, Kessler BM.
The FEBS Journal 2010 Jun; 277(11):2515.
Application：WB-Tr, Human, HEK293T cells, Monocytes.
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Post-translational modification of the deubiquitinating enzyme otubain 1 modulates active RhoA levels and susceptibility to Yersinia invasion.
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