Western blot analysis of BMP2K over-expressed 293 cell line, cotransfected with BMP2K Validated Chimera RNAi ( Cat # H00055589-R01V ) (Lane 2) or non-transfected control (Lane 1). Blot probed with BMP2K monoclonal antibody (M03) clone X1 (Cat # H00055589-M03 ). GAPDH ( 36.1 kDa ) used as specificity and loading control.
This gene is the human homolog of mouse BMP-2-inducible kinase. Bone morphogenic proteins (BMPs) play a key role in skeletal development and patterning. Expression of the mouse gene is increased during BMP-2 induced differentiation and the gene product is a putative serine/threonine protein kinase containing a nuclear localization signal. Therefore, the protein encoded by this human homolog is thought to be a protein kinase with a putative regulatory role in attenuating the program of osteoblast differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq