DHTKD1 purified MaxPab mouse polyclonal antibody (B01P)
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More Files
- More Functions
Western Blot (Tissue lysate)
DHTKD1 MaxPab polyclonal antibody. Western Blot analysis of DHTKD1 expression in human liver.
Western Blot (Cell lysate)
DHTKD1 MaxPab polyclonal antibody. Western Blot analysis of DHTKD1 expression in A-431.
Western Blot (Transfected lysate)
Western Blot analysis of DHTKD1 expression in transfected 293T cell line (H00055526-T02) by DHTKD1 MaxPab polyclonal antibody.
Lane 1: DHTKD1 transfected lysate(101.09 KDa).
Lane 2: Non-transfected lysate.
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Specification
Product Description
Mouse polyclonal antibody raised against a full-length human DHTKD1 protein.
Immunogen
DHTKD1 (NP_061176.3, 1 a.a. ~ 919 a.a) full-length human protein.
Sequence
MASATAAAARRGLGRALPLLWRGYQTERGVYGYRPRKPESREPQGALERPPVDHGLARLVTVYCEHGHKAAKINPLFTGQALLENVPEIQALVQTLQGPFHTAGLLNMGKEEASLEEVLVYLNQIYCGQISIETSQLQSQDEKDWFAKRFEELQKETFTTEERKHLSKLMLESQEFDHFLATKFSTVKRYGGEGAESMMGFFHELLKMSAYSGITDVIIGMPHRGRLNLLTGLLQFPPELMFRKMRGLSEFPENFSATGDVLSHLTSSVDLYFGAHHPLHVTMLPNPSHLEAVNPVAVGKTRGRQQSRQDGDYSPDNSAQPGDRVICLQVHGDASFCGQGIVPETFTLSNLPHFRIGGSVHLIVNNQLGYTTPAERGRSSLYCSDIGKLVGCAIIHVNGDSPEEVVRATRLAFEYQRQFRKDVIIDLLCYRQWGHNELDEPFYTNPIMYKIIRARKSIPDTYAEHLIAGGLMTQEEVSEIKSSYYAKLNDHLNNMAHYRPPALNLQAHWQGLAQPEAQITTWSTGVPLDLLRFVGMKSVEVPRELQMHSHLLKTHVQSRMEKMMDGIKLDWATAEALALGSLLAQGFNVRLSGQDVGRGTFSQRHAIVVCQETDDTYIPLNHMDPNQKGFLEVSNSPLSEEAVLGFEYGMSIESPKLLPLWEAQFGDFFNGAQIIFDTFISGGEAKWLLQSGIVILLPHGYDGAGPDHSSCRIERFLQMCDSAEEGVDGDTVNMFVVHPTTPAQYFHLLRRQMVRNFRKPLIVASPKMLLRLPAAVSTLQEMAPGTTFNPVIGDSSVDPKKVKTLVFCSGKHFYSLVKQRESLGAKKHDFAIIRVEELCPFPLDSLQQEMSKYKHVKDHIWSQEEPQNMGPWSFVSPRFEKQLACKLRLVGRPPLPVPAVGIGTVHLHQHEDILAKTFA
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (89); Rat (89)
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Tissue lysate)
DHTKD1 MaxPab polyclonal antibody. Western Blot analysis of DHTKD1 expression in human liver.Western Blot (Cell lysate)
DHTKD1 MaxPab polyclonal antibody. Western Blot analysis of DHTKD1 expression in A-431.Western Blot (Transfected lysate)
Western Blot analysis of DHTKD1 expression in transfected 293T cell line (H00055526-T02) by DHTKD1 MaxPab polyclonal antibody.
Lane 1: DHTKD1 transfected lysate(101.09 KDa).
Lane 2: Non-transfected lysate.
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Gene Info — DHTKD1
Entrez GeneID
55526GeneBank Accession#
NM_018706Protein Accession#
NP_061176.3Gene Name
DHTKD1
Gene Alias
DKFZp762M115, KIAA1630, MGC3090
Gene Description
dehydrogenase E1 and transketolase domain containing 1
Gene Ontology
HyperlinkOther Designations
OTTHUMP00000019087|dehydrogenase E1 and transketolase domain containing protein 1
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Interactome
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Disease
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Publication Reference
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Isoforms of the DHTKD1-Encoded 2-Oxoadipate Dehydrogenase, Identified in Animal Tissues, Are not Observed upon the Human DHTKD1 Expression in Bacterial or Yeast Systems.
A I Boyko, A V Artiukhov, T Kaehne, M L di Salvo, M C Bonaccorsi di Patti, R Contestabile, A Tramonti, V I Bunik.
Biochemistry. Biokhimiia 2020 Aug; 85(8):920.
Application：WB-Re, WB-Ti, Rat, Rat brain, Rat heart, Rat liver, Recombinant proteins.
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DHTKD1 deficiency causes Charcot-Marie-Tooth disease in mice.
Xu WY, Zhu H, Shen Y, Wan YH, Tu XD, Wu WT, Tang L, Zhang HX, Lu SY, Jin XL, Fei J, Wang ZG.
Molecular and Cellular Biology 2018 Jun; 38(13):e00085.
Application：IHC-P, WB-Ti, Mouse, Liver, Kidney.
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Genetic basis of alpha-aminoadipic and alpha-ketoadipic aciduria.
Hagen J, Te Brinke H, Wanders RJ, Knegt AC, Oussoren E, Hoogeboom AJ, Ruijter GJ, Becker D, Schwab KO, Franke I, Duran M, Waterham HR, Sass JO, Houten SM.
Journal of Inherited Metabolic Disease 2015 Sep; 38(5):873.
Application：Immunoblotting, Human, Fibroblasts.
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DHTKD1 is essential for mitochondrial biogenesis and function maintenance.
Xu W, Zhu H, Gu M, Luo Q, Ding J, Yao Y, Chen F, Wang Z.
FEBS Letters 2013 Nov; 587(21):3587.
Application：WB-Tr, Human, HepG2 cells.
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Isoforms of the DHTKD1-Encoded 2-Oxoadipate Dehydrogenase, Identified in Animal Tissues, Are not Observed upon the Human DHTKD1 Expression in Bacterial or Yeast Systems.
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