PSARL monoclonal antibody (M02), clone 4F4
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Specification
Product Description
Mouse monoclonal antibody raised against a partial recombinant PSARL.
Immunogen
PSARL (NP_061092.3, 2 a.a. ~ 100 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
AWRGWAQRGWGCGQAWGASVGGRSCEELTAVLTPPQLLGRRFNFFIQQKCGFRKAPRKVEPRRSDPGTSGEAYKRSALIPPVEETVFYPSPYPIRSLIK
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (90); Rat (89)
Isotype
IgG2b Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged PARL is 1 ng/ml as a capture antibody.ELISA
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Gene Info — PARL
Entrez GeneID
55486GeneBank Accession#
NM_018622Protein Accession#
NP_061092.3Gene Name
PARL
Gene Alias
PRO2207, PSARL, PSARL1, PSENIP2, RHBDS1
Gene Description
presenilin associated, rhomboid-like
Omim ID
607858Gene Ontology
HyperlinkGene Summary
This gene encodes a mitochondrial integral membrane protein. Following proteolytic processing of this protein, a small peptide (P-beta) is formed and translocated to the nucleus. This gene may be involved in signal transduction via regulated intramembrane proteolysis of membrane-tethered precursor proteins. Variation in this gene has been associated with increased risk for type 2 diabetes. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq
Other Designations
mitochondrial intramembrane-cleaving protease PARL|rhomboid 7 homolog 1
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Interactome
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Disease
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