PARL rabbit monoclonal antibody
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Specification
Product Description
Rabbit monoclonal antibody raised against a human PARL peptide using ARM Technology.
Immunogen
A synthetic peptide of human PARL is used for rabbit immunization.
Customer or Abnova will decide on the preferred peptide sequence.Host
Rabbit
Library Construction
Non-fusion antibody library from rabbit spleen (ARM Technology).
Expression
Overexpression vector and transfection into 293H cell line.
Reactivity
Human
Purification
Protein A
Isotype
IgG
Quality Control Testing
Antibody reactive against human PARL peptide by ELISA and mammalian transfected lysate by Western Blot.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Deliverable
Up to three rabbit IgG clones of 100 ug each will be delivered to customer.
Note
1. Customer may provide cell or tissue lysate for antibody screening.
2. Rabbit monoclonal antibody generated by ARM technology is amenable to antibody engineering including F(ab)2, IgG, scFv and different Fc and non-Fc conjugates per customer request. -
Applications
Western Blot (Transfected lysate)
ELISA
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Gene Info — PARL
Entrez GeneID
55486GeneBank Accession#
PARLGene Name
PARL
Gene Alias
PRO2207, PSARL, PSARL1, PSENIP2, RHBDS1
Gene Description
presenilin associated, rhomboid-like
Omim ID
607858Gene Ontology
HyperlinkGene Summary
This gene encodes a mitochondrial integral membrane protein. Following proteolytic processing of this protein, a small peptide (P-beta) is formed and translocated to the nucleus. This gene may be involved in signal transduction via regulated intramembrane proteolysis of membrane-tethered precursor proteins. Variation in this gene has been associated with increased risk for type 2 diabetes. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq
Other Designations
mitochondrial intramembrane-cleaving protease PARL|rhomboid 7 homolog 1
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Interactome
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Disease
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