LARP6 purified MaxPab mouse polyclonal antibody (B01P)
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More Files
- More Functions
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Specification
Product Description
Mouse polyclonal antibody raised against a full-length human LARP6 protein.
Immunogen
LARP6 (NP_060827, 1 a.a. ~ 491 a.a) full-length human protein.
Sequence
MAQSGGEARPGPKTAVQIRVAIQEAEDVDELEDEEEGAETRGAGDPARYLSPGWGSASEEEPSRGHSGTTASGGENEREDLEQEWKPPDEELIKKLVDQIEFYFSDENLEKDAFLLKHVRRNKLGYVSVKLLTSFKKVKHLTRDWRTTAHALKYSVVLELNEDHRKVRRTTPVPLFPNENLPSKMLLVYDLYLSPKLWALATPQKNGRVQEKVMEHLLKLFGTFGVISSVRILKPGRELPPDIRRISSRYSQVGTQECAIVEFEEVEAAIKAHEFMITESQGKENMKAVLIGMKPPKKKPAKDKNHDEEPTASIHLNKSLNKRVEELQYMGDESSANSSSDPESNPTSPMAGRRHAATNKLSPSGHQNLFLSPNASPCTSPWSSPLAQRKGVSRKSPLAEEGRLNCSTSPEIFRKCMDYSSDSSVTPSGSPWVRRRRQAEMGTQEKSPGTSPLLSRKMQTADGLPVGVLRLPRGPDNTRGFHGHERSRACV
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (91); Rat (89)
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Transfected lysate)
Western Blot analysis of LARP6 expression in transfected 293T cell line (H00055323-T02) by LARP6 MaxPab polyclonal antibody.
Lane 1: LARP6 transfected lysate(54.01 KDa).
Lane 2: Non-transfected lysate.
Immunofluorescence
Immunofluorescence of purified MaxPab antibody to LARP6 on HeLa cell. [antibody concentration 10 ug/ml] -
Gene Info — LARP6
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Interactome
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Publication Reference
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Inhibitory Effect of Mitoxantrone on Collagen Synthesis in Dermal Fibroblasts.
Kyung-Il Kim, Chang-Il Kwon, Jeung-Hoon Lee, Chang-Deok Kim, Tae-Jin Yoon.
Annals of Dermatology 2022 Jun; 34(3):206.
Application:WB, Human, Fibroblast.
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Parity predisposes breasts to the oncogenic action of PAPP-A and activation of the collagen receptor DDR2.
Slocum E, Craig A, Villanueva A, Germain D.
Breast cancer Research 2019 May; 21(1):56.
Application:WB, Mouse, Mouse mammary glands.
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mTORC1 phosphorylates LARP6 to stimulate type I collagen expression.
Zhang Y, Stefanovic B.
Scientific Reports 2017 Jan; 7:41173.
Application:WB, Human, Human lung fibroblasts (HLFs).
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Role of LARP6 and Nonmuscle Myosin in Partitioning of Collagen mRNAs to the ER Membrane.
Wang H, Stefanovic B.
PLoS One 2014 Oct; 9(10):e108870.
Application:WB-Tr, Human, Human lung fibroblasts.
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Insulin-Like Growth Factor-1 Increases Synthesis of Collagen Type I via Induction of the mRNA-Binding Protein LARP6 Expression and Binding to the 5' Stem-loop of Col1a1 and Col1a2 mRNA.
Blackstock C, Higashi Y, Sukhanov S, Shai SY, Stefanovic B, Tabony AM, Yoshida T, Delafontaine P.
The Journal of Biological Chemistry 2014 Mar; 289(11):7264.
Application:IP, WB-Ce, WB-Tr, Human, Human aortic smooth muscle cells.
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Serine-Threonine Kinase Receptor-Associated Protein (STRAP) Regulates Translation of Type I Collagen mRNAs.
Vukmirovic M, Manojlovic Z, Stefanovic B.
Molecular and Cellular Biology 2013 Oct; 33(19):3893.
Application:IP-WB, Human, HEK 293T cells.
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Tacrolimus (FK506) Prevents Early Stages of Ethanol Induced Hepatic Fibrosis by Targeting LARP6 Dependent Mechanism of Collagen Synthesis.
Manojlovic Z, Blackmon J, Stefanovic B.
PLoS One 2013 Jun; 8(6):e65897.
Application:WB-Ce, Human, Human lung fibroblasts.
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A novel role of RNA helicase A in regulation of translation of type I collagen mRNAs.
Manojlovic Z, Stefanovic B.
RNA 2011 Dec; 18(2:321.
Application:WB, Human, HEK 293 cells.
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A Novel Role of Vimentin Filaments: Binding and Stabilization of Collagen mRNAs.
Challa AA, Stefanovic B.
Molecular and Cellular Biology 2011 Sep; 31(18):3773.
Application:WB-Ce, WB-Tr, Human, Lung fibroblasts.
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Nonmuscle myosin dependent synthesis of type I collagen.
Cai L, Fritz D, Stefanovic L, Stefanovic B.
Journal of Molecular Biology 2010 Aug; 401(4):564.
Application:IP, Human, Mouse, Human lung fibroblasts, MEFs.
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Binding of LARP6 to the Conserved 5' Stem-Loop Regulates Translation of mRNAs Encoding Type I Collagen.
Cai L, Fritz D, Stefanovic L, Stefanovic B.
Journal of Molecular Biology 2009 Nov; 395(2):309.
Application:IF, WB, Human , HEK 293 cells.
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Inhibitory Effect of Mitoxantrone on Collagen Synthesis in Dermal Fibroblasts.
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