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FBXW7 293T Cell Transient Overexpression Lysate(Denatured)

  • Catalog # : H00055294-T02
  • Visit Frequency :
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  • Specification
  • Transfected Cell Line:
  • 293T
  • Plasmid:
  • pCMV-FBXW7 full-length
  • Host:
  • Human
  • Theoretical MW (kDa):
  • 70.3
  • Quality Control Testing:
  • Transient overexpression cell lysate was tested with Anti-FBXW7 antibody (H00055294-D01P) by Western Blots.
    SDS-PAGE Gel
    QC Testing of H00055294-T02
    FBXW7 transfected lysate.
    Western Blot
    QC Testing of H00055294-T02
    Lane 1: FBXW7 transfected lysate ( 70.3 KDa)
    Lane 2: Non-transfected lysate.
  • Storage Buffer:
  • 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
  • Storage Instruction:
  • Store at -80°C. Aliquot to avoid repeated freezing and thawing.
  • Applications
  • Western Blot
  • Application Image
  • Western Blot
  • Gene Information
  • Gene Name:
  • FBXW7
  • Gene Alias:
  • AGO,CDC4,DKFZp686F23254,FBW6,FBW7,FBX30,FBXO30,FBXW6,FLJ16457,SEL-10,SEL10
  • Gene Description:
  • F-box and WD repeat domain containing 7
  • Gene Summary:
  • This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene was previously referred to as FBX30, and belongs to the Fbws class; in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq
  • Other Designations:
  • F-box and WD-40 domain protein 7 (archipelago homolog, Drosophila),F-box protein FBW7,F-box protein SEL-10,archipelago homolog,archipelago, Drosophila, homolog of,homolog of C elegans sel-10
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