ATAD3A MaxPab rabbit polyclonal antibody (D01)
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More Files
- More Functions
Western Blot (Tissue lysate)
ATAD3A MaxPab rabbit polyclonal antibody. Western Blot analysis of ATAD3A expression in mouse kidney.
Western Blot (Tissue lysate)
ATAD3A MaxPab rabbit polyclonal antibody. Western Blot analysis of ATAD3A expression in human placenta.
Western Blot (Cell lysate)
ATAD3A MaxPab rabbit polyclonal antibody. Western Blot analysis of ATAD3A expression in HeLa.
Western Blot (Transfected lysate)
Western Blot analysis of ATAD3A expression in transfected 293T cell line (H00055210-T01) by ATAD3A MaxPab polyclonal antibody.
Lane 1: ATAD3A transfected lysate(66.20 KDa).
Lane 2: Non-transfected lysate.
Immunoprecipitation
Immunoprecipitation of ATAD3A transfected lysate using anti-ATAD3A MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead, and immunoblotted with ATAD3A purified MaxPab mouse polyclonal antibody (B01P) (H00055210-B01P).
Immunofluorescence
Immunofluorescence of purified MaxPab antibody to ATAD3A on HeLa cell. [antibody concentration 10 ug/ml]
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Specifications
Product Description
Rabbit polyclonal antibody raised against a full-length human ATAD3A protein.
Immunogen
ATAD3A (AAH33109.1, 1 a.a. ~ 586 a.a) full-length human protein.
Sequence
MSWLFGINKGPKGEGAGPPPPLPPAQPGAEGGGDRGLGDRPAPKDKWSNFDPTGLERAAKAARELEHSRYAKDALNLAQMQEQTLQLEQQSKLKEYEAAVEQLKSEQIRAQAEERRKTLSEETRQHQARAQYQDKLARQRYEDQLKQQQLLNEENLRKQEESVQKQEAMRRATVEREMELRHKNEMLRVEAEARARAKAERENADIIREQIRLKAAEHRQTVLESIRTAGTLFGEGFRAFVTDWDKVTATVAGLTLLAVGVYSAKNATLVAGRFIEARLGKPSLVRETSRITVLEALRHPIQVSRRLLSRPQDALEGVVLSPSLEARVRDIAIATRNTKKNRSLYRNILMYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVAPMGREGVTAMHKLFDWANTSRRGLLLFVDEADAFLRKRATEKISEDLRATLNAFLYRTGQHSNKFMLVLASNQPEQFDWAINDRINEMVHFDLPGQEERERLVRMYFDKYVLKPATEGKQRLKLAQFDYGRKCSEVARLTEGMSGREIAQLAVSWQATAYASEDGVLTEAMMDTRVQDAVQQHQQKMCWLKAEGPGRGDEPSPS
Host
Rabbit
Reactivity
Human, Mouse
Interspecies Antigen Sequence
Mouse (93); Rat (93)
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
No additive
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Tissue lysate)
ATAD3A MaxPab rabbit polyclonal antibody. Western Blot analysis of ATAD3A expression in mouse kidney.Western Blot (Tissue lysate)
ATAD3A MaxPab rabbit polyclonal antibody. Western Blot analysis of ATAD3A expression in human placenta.Western Blot (Cell lysate)
ATAD3A MaxPab rabbit polyclonal antibody. Western Blot analysis of ATAD3A expression in HeLa.Western Blot (Transfected lysate)
Western Blot analysis of ATAD3A expression in transfected 293T cell line (H00055210-T01) by ATAD3A MaxPab polyclonal antibody.
Lane 1: ATAD3A transfected lysate(66.20 KDa).
Lane 2: Non-transfected lysate.
Immunoprecipitation
Immunoprecipitation of ATAD3A transfected lysate using anti-ATAD3A MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead, and immunoblotted with ATAD3A purified MaxPab mouse polyclonal antibody (B01P) (H00055210-B01P).Immunofluorescence
Immunofluorescence of purified MaxPab antibody to ATAD3A on HeLa cell. [antibody concentration 10 ug/ml] -
Gene Info — ATAD3A
Entrez GeneID
55210GeneBank Accession#
BC033109.1Protein Accession#
AAH33109.1Gene Name
ATAD3A
Gene Alias
FLJ10709
Gene Description
ATPase family, AAA domain containing 3A
Gene Ontology
HyperlinkGene Summary
ATAD3A and ATAD3B (MIM 612317) are mitochondrial membrane proteins that contribute to the stabilization of large mitochondrial DNA (mtDNA)-protein complexes called nucleoids (He et al., 2007 [PubMed 17210950]).[supplied by OMIM
Other Designations
OTTHUMP00000000596
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Interactomes
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Publication Reference
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"ATAD3C regulates ATAD3A assembly and function in the mitochondrial membrane".
Paula Gaudó, Elena de Tomás-Mateo, Nuria Garrido-Pérez, Alfredo Santana, Eduardo Ruiz-Pesini, Julio Montoya, Pilar Bayona-Bafaluy.
Free Radical Biology & Medicine 2024 Feb; 211:114.
Application：Co-IP, Human, HEK 293T cells.
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Sigma-1 receptor maintains ATAD3A as a monomer to inhibit mitochondrial fragmentation at the mitochondria-associated membrane in amyotrophic lateral sclerosis.
Seiji Watanabe, Mai Horiuchi, Yuri Murata, Okiru Komine, Noe Kawade, Akira Sobue, Koji Yamanaka.
Neurobiology of Disease 2023 Feb; 179:106031.
Application：IF, Human, Mouse, Hela cells, Spinal cord neuron.
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Loss of mitochondrial ATPase ATAD3A contributes to non-alcoholic fatty liver disease through accumulation of lipids and damaged mitochondria.
Liting Chen, Yuchang Li, Chantal Sottas, Anthoula Lazaris, Stephanie K. Petrillo, Peter Metrakos, Lu Li, Yuji Ishida, Takeshi Saito, Samuel Garza, Vassilios Papadopoulos.
The Journal of Biological Chemistry 2022 May; 102008.
Application：IF, WB, Human, Rat, Huh-7 cells, Rat liver.
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ATAD3A oligomerization promotes neuropathology and cognitive deficits in Alzheimer's disease models.
Yuanyuan Zhao, Di Hu, Rihua Wang, Xiaoyan Sun, Philip Ropelewski, Zita Hubler, Kathleen Lundberg, Quanqiu Wang, Drew J Adams, Rong Xu, Xin Qi.
Nature Communications 2022 Mar; 13(1):1121.
Application：WB-Ce, We-Ti, WB-Tr, Human, Mouse, HT-22 cells, Human hippocampus, Mouse brain, Mouse cortex, Mouse hippocampus, N2a cells.
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AMBRA1 regulates mitophagy by interacting with ATAD3A and promoting PINK1 stability.
Martina Di Rienzo, Alessandra Romagnoli, Fabiola Ciccosanti, Giulia Refolo, Veronica Consalvi, Giuseppe Arena, Enza Maria Valente, Mauro Piacentini, Gian Maria Fimia.
Autophagy 2021 Nov; 1.
Application：IP-WB, WB-Ce, Human, HeLa, SH-SY5Y cells.
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Fatal perinatal mitochondrial cardiac failure caused by recurrent de novo duplications in the ATAD3 locus.
Ann E Frazier, Alison G Compton, Yoshihito Kishita, Daniella H Hock, AnneMarie E Welch, Sumudu S C Amarasekera, Rocio Rius, Luke E Formosa, Atsuko Imai-Okazaki, David Francis, Min Wang, Nicole J Lake, Simone Tregoning, Jafar S Jabbari, Alexis Lucattini, Kazuhiro R Nitta, Akira Ohtake, Kei Murayama, David J Amor, George McGillivray, Flora Y Wong, Marjo S van der Knaap, R Jeroen Vermeulen, Esko J Wiltshire, Janice M Fletcher, Barry Lewis, Gareth Baynam, Carolyn Ellaway, Shanti Balasubramaniam, Kau
Med (New York, N.Y.) 2021 Jan; 2(1):49.
Application：WB-Ce, WB-Tr, Human, HEK 293FT cells, Human (Patients) skin fibroblasts.
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ATAD3A oligomerization causes neurodegeneration by coupling mitochondrial fragmentation and bioenergetics defects.
Zhao Y, Sun X, Hu D, Prosdocimo DA, Hoppel C, Jain MK, Ramachandran R, Qi X.
Nature Communications 2019 Mar; 10(1):1371.
Application：IEM, IF, IP, WB, Human, Mouse, Brains, Fibroblasts, HdhQ7, HdhQ111, Striatal cells.
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Priming of dendritic cells by DNA-containing extracellular vesicles from activated T cells through antigen-driven contacts.
Torralba D, Baixauli F, Villarroya-Beltri C, Fernández-Delgado I, Latorre-Pellicer A, Acín-Pérez R, Martín-Cófreces NB, Jaso-Tamame ÁL, Iborra S, Jorge I, González-Aseguinolaza G, Garaude J, Vicente-Manzanares M, Enríquez JA, Mittelbrunn M, Sánchez-Madrid F.
Nature Communications 2018 Jul; 9(1):2658.
Application：WB, WB-Tr, Human, Primary human T lymphoblasts, J77 cells.
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Atad3 Function Is Essential for Early Post-Implantation Development in the Mouse.
Goller T, Seibold UK, Kremmer E, Voos W, Kolanus W.
PLoS One 2013 Jan; 8(1):e54799.
Application：WB, IF, Human, Mouse, Mouse embryos, ES cell, Human HeLa.
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"ATAD3C regulates ATAD3A assembly and function in the mitochondrial membrane".
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