Immunoprecipitation of THAP1 transfected lysate using anti-THAP1 MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead (U0007), and immunoblotted with THAP1 purified MaxPab mouse polyclonal antibody (B01P) (H00055145-B01P).
The protein encoded by this gene contains a THAP domain, a conserved DNA-binding domain. This protein colocalizes with the apoptosis response protein PAWR/PAR-4 in promyelocytic leukemia (PML) nuclear bodies, and functions as a proapoptotic factor that links PAWR to PML nuclear bodies. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq
4833431A01Rik,THAP domain protein 1,nuclear proapoptotic factor