XAF1 monoclonal antibody (M05), clone 3E5
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More Files
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Western Blot (Cell lysate)
XAF1 monoclonal antibody (M05), clone 3E5. Western Blot analysis of XAF1 expression in Hela S3 NE(Cat # L013V3 ).
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Specification
Product Description
Mouse monoclonal antibody raised against a partial recombinant XAF1.
Immunogen
XAF1 (NP_059993.2, 202 a.a. ~ 301 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
QTSTMEKDVRPKTRSINRFPLHSESSSKKAPRSKNKTLDPLLMSEPKPRTSSPRGDKAAYDILRRCSQCGILLPLPILNQHQEKCRWLASSKGKQVRNFS
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (45); Rat (49)
Isotype
IgG2a Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Cell lysate)
XAF1 monoclonal antibody (M05), clone 3E5. Western Blot analysis of XAF1 expression in Hela S3 NE(Cat # L013V3 ).ELISA
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Gene Info — XAF1
Entrez GeneID
54739GeneBank Accession#
NM_017523Protein Accession#
NP_059993.2Gene Name
XAF1
Gene Alias
BIRC4BP, HSXIAPAF1, XIAPAF1
Gene Description
XIAP associated factor 1
Omim ID
606717Gene Ontology
HyperlinkGene Summary
X-linked inhibitor of apoptosis (XIAP; MIM 300079) is a potent member of the IAP family. All members of this family possess baculoviral IAP (BIR) repeats, cysteine-rich domains of approximately 80 amino acids that bind and inhibit caspases (e.g., CASP3; MIM 600636). XIAP has 3 BIR domains and a C-terminal RING zinc finger that possesses E3 ubiquitin ligase (see MIM 601623) activity. XAF1 antagonizes the anticaspase activity of XIAP and may be important in mediating apoptosis resistance in cancer cells (Liston et al., 2001 [PubMed 11175744]).[supplied by OMIM
Other Designations
BIRC4 binding protein
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