UGT1A6 293T Cell Transient Overexpression Lysate(Denatured)
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More Files
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-UGT1A6 full-length
Host
Human
Theoretical MW (kDa)
58.63
Interspecies Antigen Sequence
Mouse (78); Rat (80)
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-UGT1A6 antibody (H00054578-B01) by Western Blots.
SDS-PAGE Gel
UGT1A6 transfected lysate.
Western Blot
Lane 1: UGT1A6 transfected lysate ( 58.63 KDa)
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — UGT1A6
Entrez GeneID
54578GeneBank Accession#
BC019861.1Protein Accession#
AAH19861.1Gene Name
UGT1A6
Gene Alias
GNT1, HLUGP, HLUGP1, MGC29860, UDPGT, UGT1, UGT1A6S, UGT1F
Gene Description
UDP glucuronosyltransferase 1 family, polypeptide A6
Omim ID
606431Gene Ontology
HyperlinkGene Summary
This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene is active on phenolic and planar compounds. Alternative splicing in the unique 5' end of this gene results in two transcript variants. [provided by RefSeq
Other Designations
OTTHUMP00000065199|UDP glycosyltransferase 1 family, polypeptide A6|UDP-glucuronosyltransferase 1 family polypeptide A6s|UDP-glucuronosyltransferase 1A6|phenol-metabolizing UDP-glucuronosyltransferase
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Pathway
- Androgen and estrogen metabolism
- Ascorbate and aldarate metabolism
- Drug metabolism - cytochrome P450
- Drug metabolism - other enzymes
- Metabolic pathways
- Metabolism of xenobiotics by cytochrome P450
- Pentose and glucuronate interconversions
- Porphyrin and chlorophyll metabolism
- Retinol metabolism
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