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Western Blot

Entrez GeneID

GeneBank Accession#

Protein Accession#

Gene Name

FBXW5

Gene Alias

DKFZp434B205, Fbw5, MGC20962, RP11-229P13.10

Gene Description

F-box and WD repeat domain containing 5

Omim ID

Gene Ontology

Gene Summary

This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains WD-40 domains, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene, however, they were found to be nonsense-mediated mRNA decay (NMD) candidates, hence not represented. [provided by RefSeq

Other Designations

F-box and WD-40 domain protein 5|OTTHUMP00000022659|WD repeat-containing F-box protein FBW5