MBD3 MaxPab rabbit polyclonal antibody (D01)
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More Files
- More Functions
Immunoprecipitation
Immunoprecipitation of MBD3 transfected lysate using anti-MBD3 MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead, and immunoblotted with MBD3 purified MaxPab mouse polyclonal antibody (B01P) (H00053615-B01P).
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Specification
Product Description
Rabbit polyclonal antibody raised against a full-length human MBD3 protein.
Immunogen
MBD3 (NP_003917.1, 1 a.a. ~ 291 a.a) full-length human protein.
Sequence
MERKRWECPALPQGWEREEVPRRSGLSAGHRDVFYYSPSGKKFRSKPQLARYLGGSMDLSTFDFRTGKMLMSKMNKSRQRVRYDSSNQVKGKPDLNTALPVRQTASIFKQPVTKITNHPSNKVKSDPQKAVDQPRQLFWEKKLSGLNAFDIAEELVKTMDLPKGLQGVGPGCTDETLLSAIASALHTSTMPITGQLSAAVEKNPGVWLNTTQPLCKAFMVTDEDIRKQEELVQQVRKRLEEALMADMLAHVEELARDGEAPLDKACAEDDDEEDEEEEEEEPDPDPEMEHV
Host
Rabbit
Reactivity
Human
Interspecies Antigen Sequence
Mouse (95); Rat (95)
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
No additive
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Immunoprecipitation
Immunoprecipitation of MBD3 transfected lysate using anti-MBD3 MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead, and immunoblotted with MBD3 purified MaxPab mouse polyclonal antibody (B01P) (H00053615-B01P). -
Gene Info — MBD3
Entrez GeneID
53615GeneBank Accession#
NM_003926.5Protein Accession#
NP_003917.1Gene Name
MBD3
Gene Alias
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Gene Description
methyl-CpG binding domain protein 3
Omim ID
603573Gene Ontology
HyperlinkGene Summary
DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). However, unlike the other family members, MBD3 is not capable of binding to methylated DNA. The predicted MBD3 protein shares 71% and 94% identity with MBD2 (isoform 1) and mouse Mbd3. MBD3 is a subunit of the NuRD, a multisubunit complex containing nucleosome remodeling and histone deacetylase activities. MBD3 mediates the association of metastasis-associated protein 2 (MTA2) with the core histone deacetylase complex. [provided by RefSeq
Other Designations
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