PANK1 (Human) Recombinant Protein (P01)
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More Files
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Specification
Product Description
Human PANK1 full-length ORF ( NP_683879.1, 1 a.a. - 373 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MKLINGKKQTFPWFGMDIGGTLVKLVYFEPKDITAEEEQEEVENLKSIRKYLTSNTAYGKTGIRDVHLELKNLTMCGRKGNLHFIRFPSCAMHRFIQMGSEKNFSSLHTTLCATGGGAFKFEEDFRMIADLQLHKLDELDCLIQGLLYVDSVGFNGKPECYYFENPTNPELCQKKPYCLDNPYPMLLVNMGSGVSILAVYSKDNYKRVTGTSLGGGTFLGLCCLLTGCETFEEALEMAAKGDSTNVDKLVKDIYGGDYERFGLQGSAVASSFGNMMSKEKRDSISKEDLARATLVTITNNIGSIARMCALNENIDRVVFVGNFLRINMVSMKLLAYAMDFWSKGQLKALFLEHEGYFGAVGALLELFKMTDDK
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
68.1
Interspecies Antigen Sequence
Mouse (96); Rat (98)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — PANK1
Entrez GeneID
53354GeneBank Accession#
NM_148978.1Protein Accession#
NP_683879.1Gene Name
PANK1
Gene Alias
MGC24596, PANK, PANK1a, PANK1b
Gene Description
pantothenate kinase 1
Omim ID
606160Gene Ontology
HyperlinkGene Summary
This gene encodes a protein belonging to the pantothenate kinase family. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by CoA. Alternative splicing has been observed at this locus and three variants, each encoding a distinct isoform, have been identified. [provided by RefSeq
Other Designations
OTTHUMP00000020071|OTTHUMP00000020072|pantothenic acid kinase
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Pathway
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Disease
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