Immunoprecipitation of BCL11A transfected lysate using anti-BCL11A MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead (U0007), and immunoblotted with BCL11A purified MaxPab mouse polyclonal antibody (B01P) (H00053335-B01P).
This gene encodes a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. The corresponding mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with BCL6. During hematopoietic cell differentiation, this gene is down-regulated. It is possibly involved in lymphoma pathogenesis since translocations associated with B-cell malignancies also deregulates its expression. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq