COQ3 monoclonal antibody (M01), clone 6D5
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More Files
- More Functions
Western Blot (Transfected lysate)
Western Blot analysis of COQ3 expression in transfected 293T cell line by COQ3 monoclonal antibody (M01), clone 6D5.
Lane 1: COQ3 transfected lysate(41 KDa).
Lane 2: Non-transfected lysate.
Western Blot detection against Immunogen (36.41 KDa) .
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Specification
Product Description
Mouse monoclonal antibody raised against a partial recombinant COQ3.
Immunogen
COQ3 (NP_059117, 273 a.a. ~ 369 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
IVPKGTHTWEKFVSPETLESILESNGLSVQTVVGMLYNPFSGYWHWSENTSLNYAAHAVKSRVQEHPASAEFVLKGETEELQANACTNPAVHEKLKK
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (73); Rat (81)
Isotype
IgG1 Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (36.41 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Transfected lysate)
Western Blot analysis of COQ3 expression in transfected 293T cell line by COQ3 monoclonal antibody (M01), clone 6D5.
Lane 1: COQ3 transfected lysate(41 KDa).
Lane 2: Non-transfected lysate.
Western Blot (Recombinant protein)
ELISA
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Gene Info — COQ3
Entrez GeneID
51805GeneBank Accession#
NM_017421Protein Accession#
NP_059117Gene Name
COQ3
Gene Alias
UG0215E05, bA9819.1
Gene Description
coenzyme Q3 homolog, methyltransferase (S. cerevisiae)
Omim ID
605196Gene Ontology
HyperlinkGene Summary
Ubiquinone, also known as coenzyme Q, or Q, is a critical component of the electron transport pathways of both eukaryotes and prokaryotes (Jonassen and Clarke, 2000 [PubMed 10777520]). This lipid consists of a hydrophobic isoprenoid tail and a quinone head group. The tail varies in length depending on the organism, but its purpose is to anchor coenzyme Q to the membrane. The quinone head group is responsible for the activity of coenzyme Q in the respiratory chain. The S. cerevisiae COQ3 gene encodes an O-methyltransferase required for 2 steps in the biosynthetic pathway of coenzyme Q. This enzyme methylates an early coenzyme Q intermediate, 3,4-dihydroxy-5-polyprenylbenzoic acid, as well as the final intermediate in the pathway, converting demethyl-ubiquinone to coenzyme Q. The COQ3 gene product is also capable of methylating the distinct prokaryotic early intermediate 2-hydroxy-6-polyprenyl phenol.[supplied by OMIM
Other Designations
OTTHUMP00000016892|methyltransferase COQ3
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Interactome
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Pathway
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Disease
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