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Entrez GeneID

GeneBank Accession#

Protein Accession#

Gene Name

WWOX

Gene Alias

D16S432E, FOR, FRA16D, HHCMA56, PRO0128, SDR41C1, WOX1

Gene Description

WW domain containing oxidoreductase

Omim ID

Gene Ontology

Gene Summary

WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 2 WW domains and a short-chain dehydrogenase/reductase domain (SRD). The highest normal expression of this gene is detected in hormonally regulated tissues such as testis, ovary, and prostate. This expression pattern and the presence of an SRD domain suggest a role for this gene in steroid metabolism. The encoded protein is more than 90% identical to the mouse protein, which is an essential mediator of tumor necrosis factor-alpha-induced apoptosis, suggesting a similar, important role in apoptosis for the human protein. In addition, there is evidence that this gene behaves as a suppressor of tumor growth. Alternative splicing of this gene generates transcript variants that encode different isoforms. [provided by RefSeq

Other Designations

WW domain-containing oxidoreductase|WW domain-containing protein WWOX|fragile 16D oxido reductase|fragile site FRA16D oxidoreductase|putative oxidoreductase|short chain dehydrogenase/reductase family 41C, member 1