DPH5 (Human) Recombinant Protein (P01)
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More Files
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Specification
Product Description
Human DPH5 full-length ORF ( NP_001070862.1, 1 a.a. - 285 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MLYLIGLGLGDAKDITVKGLEVVRRCSRVYLEAYTSVLTVGKEALEEFYGRKLVVADREEVEQEADNILKDADISDVAFLVVGDPFGATTHSDLVLRATKLGIPYRVIHNASIMNAVGCCGLQLYKFGETVSIVFWTDTWRPESFFDKVKKNRQNGMHTLCLLDIKVKEQSLENLIKGRKIYEPPRYMSVNQAAQQLLEIVQNQRIRGEEPAVTEETLCVGLARVGADDQKIAAGTLRQMCTVDLGEPLHSLIITGGSIHPMEMEMLSLFSIPENSSESQSINGL
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
58.1
Interspecies Antigen Sequence
Mouse (91); Rat (91)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — DPH5
Entrez GeneID
51611GeneBank Accession#
NM_001077394.1Protein Accession#
NP_001070862.1Gene Name
DPH5
Gene Alias
AD-018, CGI-30, HSPC143, MGC61450, NPD015
Gene Description
DPH5 homolog (S. cerevisiae)
Omim ID
611075Gene Ontology
HyperlinkGene Summary
This gene encodes a component of the diphthamide synthesis pathway. Diphthamide is a post-translationally modified histidine residue found only on translation elongation factor 2. It is conserved from archaebacteria to humans, and is targeted by diphtheria toxin and Pseudomonas exotoxin A to halt cellular protein synthesis. The yeast and Chinese hamster homologs of this protein catalyze the trimethylation of the histidine residue on elongation factor 2, resulting in a diphthine moiety that is subsequently amidated to yield diphthamide. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000012522|OTTHUMP00000012523|OTTHUMP00000012524|diphthamide biosynthesis methyltransferase|diphthine synthase|protein x 0011
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