Products

Immunoprecipitation-Western Blot

Entrez GeneID

Gene Name

ATP6V1H

Gene Alias

CGI-11, MSTP042, NBP1, SFD, SFDalpha, SFDbeta, VMA13

Gene Description

ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H

Omim ID

Gene Ontology

Gene Summary

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes the regulatory H subunit of the V1 domain which is required for catalysis of ATP but not the assembly of V-ATPase. Three alternatively spliced transcript variants encode two isoforms of the H subunit. [provided by RefSeq

Other Designations

ATPase, H+ transporting, lysosomal 50/57kD, V1 subunit H|V-ATPase H subunit|vacuolar ATP synthase subunit H|vacuolar ATPase subunit H|vacuolar proton pump H subunit