Western blot analysis of HDAC7A over-expressed 293 cell line, cotransfected with HDAC7A Validated Chimera RNAi ( Cat # H00051564-R01V ) (Lane 2) or non-transfected control (Lane 1). Blot probed with HDAC7A monoclonal antibody (M01), clone 2B11-1C1 (Cat # H00051564-M01 ). GAPDH ( 36.1 kDa ) used as specificity and loading control.
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to mouse HDAC7 gene whose protein promotes repression mediated via the transcriptional corepressor SMRT. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq