SPG21 (Human) Recombinant Protein (P01)
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More Files
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Specifications
Product Description
Human SPG21 full-length ORF ( NP_057714.1, 1 a.a. - 308 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MGEIKVSPDYNWFRGTVPLKKIIVDDDDSKIWSLYDAGPRSIRCPLIFLPPVSGTADVFFRQILALTGWGYRVIALQYPVYWDHLEFCDGFRKLLDHLQLDKVHLFGASLGGFLAQKFAEYTHKSPRVHSLILCNSFSDTSIFNQTWTANSFWLMPAFMLKKIVLGNFSSGPVDPMMADAIDFMVDRLESLGQSELASRLTLNCQNSYVEPHKIRDIPVTIMDVFDQSALSTEAKEEMYKLYPNARRAHLKTGGNFPYLCRSAEVNLYVQIHLLQFHGTKYAAIDPSMVSAEELEVQKGSLGISQEEQ
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
61.4
Interspecies Antigen Sequence
Mouse (98); Rat (82)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — SPG21
Entrez GeneID
51324GeneBank Accession#
NM_016630.3Protein Accession#
NP_057714.1Gene Name
SPG21
Gene Alias
ACP33, BM-019, GL010, MASPARDIN, MAST
Gene Description
spastic paraplegia 21 (autosomal recessive, Mast syndrome)
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene was identified by a two-hybrid screen using CD4 as the bait. It binds to the hydrophobic C-terminal amino acids of CD4 which are involved in repression of T cell activation. The interaction with CD4 is mediated by the noncatalytic alpha/beta hydrolase fold domain of this protein. It is thus proposed that this gene product modulates the stimulatory activity of CD4. At least three different transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq
Other Designations
acid cluster protein 33|spastic paraplegia 21
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