SPG21 monoclonal antibody (M01), clone 2B11
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More Files
- More Functions
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged SPG21 is 0.3 ng/ml as a capture antibody.
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Specification
Product Description
Mouse monoclonal antibody raised against a partial recombinant SPG21.
Immunogen
SPG21 (NP_057714, 211 a.a. ~ 306 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
PHKIRDIPVTIMDVFDQSALSTEAKEEMYKLYPNARRAHLKTGGNFPYLCRSAEVNLYVQIHLLQFHGTKYAAIDPSMVSAEELEVQKGSLGISQE
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (98); Rat (82)
Isotype
IgG2a Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged SPG21 is 0.3 ng/ml as a capture antibody.ELISA
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Gene Info — SPG21
Entrez GeneID
51324GeneBank Accession#
NM_016630Protein Accession#
NP_057714Gene Name
SPG21
Gene Alias
ACP33, BM-019, GL010, MASPARDIN, MAST
Gene Description
spastic paraplegia 21 (autosomal recessive, Mast syndrome)
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene was identified by a two-hybrid screen using CD4 as the bait. It binds to the hydrophobic C-terminal amino acids of CD4 which are involved in repression of T cell activation. The interaction with CD4 is mediated by the noncatalytic alpha/beta hydrolase fold domain of this protein. It is thus proposed that this gene product modulates the stimulatory activity of CD4. At least three different transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq
Other Designations
acid cluster protein 33|spastic paraplegia 21
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