Products

Western Blot (Cell lysate)

Western Blot (Recombinant protein)

ELISA

Entrez GeneID

GeneBank Accession#

Protein Accession#

Gene Name

SPG21

Gene Alias

ACP33, BM-019, GL010, MASPARDIN, MAST

Gene Description

spastic paraplegia 21 (autosomal recessive, Mast syndrome)

Omim ID

Gene Ontology

Gene Summary

The protein encoded by this gene was identified by a two-hybrid screen using CD4 as the bait. It binds to the hydrophobic C-terminal amino acids of CD4 which are involved in repression of T cell activation. The interaction with CD4 is mediated by the noncatalytic alpha/beta hydrolase fold domain of this protein. It is thus proposed that this gene product modulates the stimulatory activity of CD4. At least three different transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq

Other Designations

acid cluster protein 33|spastic paraplegia 21