CRBN (Human) Recombinant Protein (P01)
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More Files
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Specification
Product Description
Human CRBN full-length ORF ( NP_057386.2, 1 a.a. - 442 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
76.9
Interspecies Antigen Sequence
Mouse (94); Rat (95)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — CRBN
Entrez GeneID
51185GeneBank Accession#
NM_016302.2Protein Accession#
NP_057386.2Gene Name
CRBN
Gene Alias
DKFZp781K0715, MGC27358, MRT2A
Gene Description
cereblon
Gene Ontology
HyperlinkGene Summary
non-syndromic
Other Designations
mental retardation, non-syndromic, autosomal recessive, 2A|protein x 0001
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Interactome
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Publication Reference
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Orally bioavailable BTK PROTAC active against wild-type and C481 mutant BTKs in human lymphoma CDX mouse models.
Ye Seul Lim, Sun-Mi Yoo, Vineet Patil, Han Wool Kim, Hyun-Hwi Kim, Beomseon Suh, Ji Youn Park, Na-rae Jeong, Chi Hoon Park, Je Ho Ryu, Byung-Hoon Lee, Pilho Kim, Song Hee Lee.
Blood Advances 2022 Oct; bloodadvances.2022008121..
Application:Func, Recombinant proteins.
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Identification of salt-inducible kinase 3 as a novel tumor antigen associated with tumorigenesis of ovarian cancer.
Charoenfuprasert S, Yang YY, Lee YC, Chao KC, Chu PY, Lai CR, Hsu KF, Chang KC, Chen YC, Chen LT, Chang JY, Leu SJ, Shih NY.
Oncogene 2011 Aug; 30(33):3570.
Application:WB-Re, As a positive control, Recombinant protein.
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Orally bioavailable BTK PROTAC active against wild-type and C481 mutant BTKs in human lymphoma CDX mouse models.
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