CRBN purified MaxPab mouse polyclonal antibody (B01P)
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More Files
- More Functions
Western Blot (Transfected lysate)
Western Blot analysis of CRBN expression in transfected 293T cell line (H00051185-T01) by CRBN MaxPab polyclonal antibody.
Lane 1: CRBN transfected lysate(48.62 KDa).
Lane 2: Non-transfected lysate.
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Specification
Product Description
Mouse polyclonal antibody raised against a full-length human CRBN protein.
Immunogen
CRBN (NP_057386.2, 1 a.a. ~ 442 a.a) full-length human protein.
Sequence
MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (94); Rat (95)
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Transfected lysate)
Western Blot analysis of CRBN expression in transfected 293T cell line (H00051185-T01) by CRBN MaxPab polyclonal antibody.
Lane 1: CRBN transfected lysate(48.62 KDa).
Lane 2: Non-transfected lysate.
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Gene Info — CRBN
Entrez GeneID
51185GeneBank Accession#
NM_016302.2Protein Accession#
NP_057386.2Gene Name
CRBN
Gene Alias
DKFZp781K0715, MGC27358, MRT2A
Gene Description
cereblon
Gene Ontology
HyperlinkGene Summary
non-syndromic
Other Designations
mental retardation, non-syndromic, autosomal recessive, 2A|protein x 0001
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Interactome
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Publication Reference
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Effects of cereblon on stress-activated redox proteins and core behavior.
Uroos Akber, Sunhwa Bong, Zee-Yong Park, Chul-Seung Park.
Brain Research 2022 oct; 1793:148054.
Application：WB, Mouse, Mouse brain tissue.
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The Neuroprotective Effect of Thalidomide against Ischemia through the Cereblon-mediated Repression of AMPK Activity.
Sawamura N, Yamada M, Fujiwara M, Yamada H, Hayashi H, Takagi N, Asahi T.
Scientific Reports 2018 Feb; 8:2459.
Application：IP-WB, Human, SH-SY5Y cells.
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CRL4A(CRBN) E3 ubiquitin ligase restricts BK channel activity and prevents epileptogenesis.
Liu J, Ye J, Zou X, Xu Z, Feng Y, Zou X, Chen Z, Li Y, Cang Y.
Nature Communications 2014 May; 5:3924.
Application：WB-Tr, Human, HEK 293T cells.
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Deficient Import of Acetyl-CoA into the ER Lumen Causes Neurodegeneration and Propensity to Infections, Inflammation, and Cancer.
Peng Y, Li M, Clarkson BD, Pehar M, Lao PJ, Hillmer AT, Barnhart TE, Christian BT, Mitchell HA, Bendlin BB, Sandor M, Puglielli L.
The Journal of Neuroscience 2014 May; 34(20):6672.
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Identification of salt-inducible kinase 3 as a novel tumor antigen associated with tumorigenesis of ovarian cancer.
Charoenfuprasert S, Yang YY, Lee YC, Chao KC, Chu PY, Lai CR, Hsu KF, Chang KC, Chen YC, Chen LT, Chang JY, Leu SJ, Shih NY.
Oncogene 2011 Aug; 30(33):3570.
Application：IHC-P, WB-Ce, Human, CA502 ascitic tumor cells, IOSE385, OVCAR3, SK-OV3 cells, Human ovarian cancer.
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Effects of cereblon on stress-activated redox proteins and core behavior.
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