NAGPA (Human) Recombinant Protein (Q01)
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More Files
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Specification
Product Description
Human NAGPA partial ORF ( NP_057340, 309 a.a. - 408 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
DNMWRCPRQVSTVVCVHEPRCQPPDCHGHGTCVDGHCQCTGHFWRGPGCDELDCGPSNCSQHGLCTETGCRCDAGWTGSNCSEECPLGWHGPGCQRPCKC
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
36.74
Interspecies Antigen Sequence
Mouse (91); Rat (87)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — NAGPA
Entrez GeneID
51172GeneBank Accession#
NM_016256Protein Accession#
NP_057340Gene Name
NAGPA
Gene Alias
APAA, UCE
Gene Description
N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
Omim ID
607985Gene Ontology
HyperlinkGene Summary
Hydrolases are transported to lysosomes after binding to mannose 6-phosphate receptors in the trans-Golgi network. This gene encodes the enzyme that catalyzes the second step in the formation of the mannose 6-phosphate recognition marker on lysosomal hydrolases. Commonly known as 'uncovering enzyme' or UCE, this enzyme removes N-acetyl-D-glucosamine (GlcNAc) residues from GlcNAc-alpha-P-mannose moieties and thereby produces the recognition marker. This reaction most likely occurs in the trans-Golgi network. This enzyme functions as a homotetramer of two disulfide-linked homodimers. In addition to having an N-terminal signal peptide, the protein's C-terminus contains multiple signals for trafficking it between lysosomes, the plasma membrane, and trans-Golgi network. [provided by RefSeq
Other Designations
alpha-N-acetylglucosaminyl phosphodiesterase|lysosomal alpha-N-acetylglucosaminidase|mannose 6-phosphate-uncovering enzyme|phosphodiester alpha-GlcNAcase
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Interactome
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Pathway
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