DHH purified MaxPab mouse polyclonal antibody (B01P)
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More Files
- More Functions
Western Blot (Transfected lysate)
Western Blot analysis of DHH expression in transfected 293T cell line (H00050846-T01) by DHH MaxPab polyclonal antibody.
Lane 1: DHH transfected lysate(43.56 KDa).
Lane 2: Non-transfected lysate.
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Specification
Product Description
Mouse polyclonal antibody raised against a full-length human DHH protein.
Immunogen
DHH (NP_066382.1, 1 a.a. ~ 396 a.a) full-length human protein.
Sequence
MALLTNLLPLCCLALLALPAQSCGPGRGPVGRRRYARKQLVPLLYKQFVPGVPERTLGASGPAEGRVARGSERFRDLVPNYNPDIIFKDEENSGADRLMTERCKERVNALAIAVMNMWPGVRLRVTEGWDEDGHHAQDSLHYEGRALDITTSDRDRNKYGLLARLAVEAGFDWVYYESRNHVHVSVKADNSLAVRAGGCFPGNATVRLWSGERKGLRELHRGDWVLAADASGRVVPTPVLLFLDRDLQRRASFVAVETEWPPRKLLLTPWHLVFAARGPAPAPGDFAPVFARRLRAGDSVLAPGGDALRPARVARVAREEAVGVFAPLTAHGTLLVNDVLASCYAVLESHQWAHRAFAPLRLLHALGALLPGGAVQPTGMHWYSRLLYRLAEELLG
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (96); Rat (96)
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Transfected lysate)
Western Blot analysis of DHH expression in transfected 293T cell line (H00050846-T01) by DHH MaxPab polyclonal antibody.
Lane 1: DHH transfected lysate(43.56 KDa).
Lane 2: Non-transfected lysate.
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Gene Info — DHH
Entrez GeneID
50846GeneBank Accession#
NM_021044.2Protein Accession#
NP_066382.1Gene Name
DHH
Gene Alias
HHG-3, MGC35145
Gene Description
desert hedgehog homolog (Drosophila)
Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the Hedgehog family. The hedgehog gene family encodes signaling molecules that play an important role in regulating morphogenesis. This protein is predicted to be made as a precursor that is autocatalytically cleaved; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the organism. Defects in this protein have been associated with partial gonadal dysgenesis (PGD) accompanied by minifascicular polyneuropathy. This protein may be involved in both male gonadal differentiation and perineurial development. [provided by RefSeq
Other Designations
desert hedgehog
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Interactome
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Pathway
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Publication Reference
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Protease nexin 1 inhibits hedgehog signaling in prostate adenocarcinoma.
McKee CM, Xu D, Cao Y, Kabraji S, Allen D, Kersemans V, Beech J, Smart S, Hamdy F, Ishkanian A, Sykes J, Pintile M, Milosevic M, van der Kwast T, Zafarana G, Ramnarine VR, Jurisica I, Mallof C, Lam W, Bristow RG, Muschel RJ.
The Journal of Clinical Investigation 2012 Nov; 122(11):4025.
Application：WB-Ce, Human, PC-3 cells.
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Protease nexin 1 inhibits hedgehog signaling in prostate adenocarcinoma.
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