RDH8 293T Cell Transient Overexpression Lysate(Denatured)
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-RDH8 full-length
Host
Human
Theoretical MW (kDa)
34.21
Interspecies Antigen Sequence
Mouse (82); Rat (83)
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-RDH8 antibody (H00050700-B01) by Western Blots.
SDS-PAGE Gel
RDH8 transfected lysate.
Western Blot
Lane 1: RDH8 transfected lysate ( 34.21 KDa)
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — RDH8
Entrez GeneID
50700GeneBank Accession#
BC146479Protein Accession#
AAI46480.1Gene Name
RDH8
Gene Alias
PRRDH, SDR28C2
Gene Description
retinol dehydrogenase 8 (all-trans)
Omim ID
608575Gene Ontology
HyperlinkGene Summary
All-trans-retinol dehydrogenase (RDH8) is a visual cycle enzyme that reduces all-trans-retinal to all-trans-retinol in the presence of NADPH (Rattner et al., 2000 [PubMed 10753906]). It is a member of the short chain dehydrogenase/reductase family and is located in the outer segments of photoreceptors; hence it is also known as photoreceptor retinol dehydrogenase. It is important in the visual cycle by beginning the rhodopsin regeneration pathway by reducing all-trans-retinal, the product of bleached and hydrolysed rhodopsin (Rando, 2001 [PubMed 11710234]). This is a rate-limiting step in the visual cycle (Saari et al., 1998 [PubMed 9667000]).[supplied by OMIM
Other Designations
photoreceptor outer segment all-trans retinol dehydrogenase|short chain dehydrogenase/reductase family 28C, member 2
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