ARHGEF3 purified MaxPab mouse polyclonal antibody (B01P)
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More Files
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Specification
Product Description
Mouse polyclonal antibody raised against a full-length human ARHGEF3 protein.
Immunogen
ARHGEF3 (AAH99715, 1 a.a. ~ 324 a.a) full-length human protein.
Sequence
MKLPCLSSYDSYCSNQVAAKALLDHKKQDHRVQDFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLLLREILRHTPNDNPDQQHLEEAINIIQGIVAEINTKTGESECRYYKERLLYLEEGQKDSLIDSSRVVCCHGELKNNRGVKLHVFLFQEVLVITRAVTHNEQLCYQLYRQPIPVKDLLLEDLQDGEVRLGGSLRGAFSNNERIKNFFRVSFKNGSQSQTHSLQANDTFNKQQWLNCIRQAKETVLCAAGQAGVLDSEGSFLNPTTGSRELQGETKLEQMDQSDSESDCSMDTSEVSLDCERMEQTDSSCGNSRHGESNV
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (94); Rat (94)
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Transfected lysate)
Western Blot analysis of ARHGEF3 expression in transfected 293T cell line (H00050650-T01) by ARHGEF3 MaxPab polyclonal antibody.
Lane 1: ARHGEF3 transfected lysate(35.64 KDa).
Lane 2: Non-transfected lysate.
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Gene Info — ARHGEF3
Entrez GeneID
50650GeneBank Accession#
BC099715Protein Accession#
AAH99715Gene Name
ARHGEF3
Gene Alias
DKFZp434F2429, FLJ98126, GEF3, MGC118905, STA3, XPLN
Gene Description
Rho guanine nucleotide exchange factor (GEF) 3
Gene Ontology
HyperlinkGene Summary
Rho-like GTPases are involved in a variety of cellular processes, and they are activated by binding GTP and inactivated by conversion of GTP to GDP by their intrinsic GTPase activity. Guanine nucleotide exchange factors (GEFs) accelerate the GTPase activity of Rho GTPases by catalyzing their release of bound GDP. This gene encodes a guanine nucleotide exchange factor, which specifically activates two members of the Rho GTPase family: RHOA and RHOB, both of which have a role in bone cell biology. It has been identified that genetic variation in this gene plays a role in the determination of bone mineral density (BMD), indicating the implication of this gene in postmenopausal osteoporosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
59.8 kDA protein|Rho guanine nucleotide exchange factor 3|RhoGEF protein|exchange factor found in platelets and leukemic and neuronal tissues, XPLN
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Interactome
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Disease
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Publication Reference
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XPLN is modulated by HDAC inhibitors and negatively regulates SPARC expression by targeting mTORC2 in human lung fibroblasts.
Kamio K, Azuma A, Usuki J, Matsuda K, Inomata M, Nishijima N, Itakura S, Hayashi H, Kashiwada T, Kokuho N, Atsumi K, Yamaguchi T, Fujita K, Saito Y, Abe S, Kubota K, Gemma A.
Amino Acids 2017 Mar; 44:61.
Application:WB, Human, HFL-1 cells.
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XPLN is modulated by HDAC inhibitors and negatively regulates SPARC expression by targeting mTORC2 in human lung fibroblasts.
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