NOX4 (Human) Recombinant Protein (Q01)
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Specification
Product Description
Human NOX4 partial ORF ( NP_058627.1, 479 a.a. - 578 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
LHNKFWQENRPDYVNIQLYLSQTDGIQKIIGEKYHALNSRLFIGRPRWKLLFDEIAKYNRGKTVGVFCCGPNSLSKTLHKLSNQNNSYGTRFEYNKESFS
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
36.74
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — NOX4
Entrez GeneID
50507GeneBank Accession#
NM_016931Protein Accession#
NP_058627.1Gene Name
NOX4
Gene Alias
KOX, KOX-1, RENOX
Gene Description
NADPH oxidase 4
Omim ID
605261Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the NOX-family of enzymes that functions as the catalytic subunit the NADPH oxidase complex. The encoded protein is localized to non-phagocytic cells where it acts as an oxygen sensor and catalyzes the reduction of molecular oxygen to various reactive oxygen species (ROS). The ROS generated by this protein have been implicated in numerous biological functions including signal transduction, cell differentiation and tumor cell growth. A pseudogene has been identified on the other arm of chromosome 11. Alternative splicing results in multiple transcript variants
Other Designations
kidney superoxide-producing NADPH oxidase|renal NAD(P)H-oxidase
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Interactome
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