RRM2B monoclonal antibody (M01), clone 6C1
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Specification
Product Description
Mouse monoclonal antibody raised against a partial recombinant RRM2B.
Immunogen
RRM2B (NP_056528, 3 a.a. ~ 84 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
DPERPEAAGLDQDERSSSDTNESEIKSNEEPLLRKSSRRFVIFPIQYPDIWKMYKQAQASFWTAEEVDLSKDLPHWNKLKAD
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (93); Rat (94)
Isotype
IgG2b Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (34.76 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Recombinant protein)
ELISA
Immunofluorescence
Immunofluorescence of monoclonal antibody to RRM2B on HeLa cell . [antibody concentration 10 ug/ml] -
Gene Info — RRM2B
Entrez GeneID
50484GeneBank Accession#
NM_015713Protein Accession#
NP_056528Gene Name
RRM2B
Gene Alias
DKFZp686M05248, MGC102856, MGC42116, p53R2
Gene Description
ribonucleotide reductase M2 B (TP53 inducible)
Omim ID
604712Gene Ontology
HyperlinkOther Designations
p53-inducible ribonucleotide reductase small subunit 2 homolog|p53-inducible ribonucleotide reductase small subunit 2 long form|p53-inducible ribonucleotide reductase small subunit 2 short form gamma
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Interactome
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Pathway
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Disease
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Publication Reference
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p53R2 regulates thioredoxin reductase activity through interaction with TrxR2.
Park SJ, Kim HB, Piao C, Kang MY, Park SG, Kim SW, Lee JH.
Biochemical and Biophysical Research Communications 2017 Jan; 482(4):706.
Application:IF, IP-WB, WB-Tr, Human, U2OS, RKO cells.
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Ribonucleotide reductase small subunit p53R2 suppresses MEK?VERK activity by binding to ERK kinase 2.
Piao C, Jin M, Kim HB, Lee SM, Amatya PN, Hyun JW, Chang IY, You HJ.
Oncogene 2009 May; 28(21):2173.
Application:IF, WB-Tr, Human, NCI-H1299, U-2 OS cells.
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p53R2 regulates thioredoxin reductase activity through interaction with TrxR2.
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