CD209 MaxPab rabbit polyclonal antibody (D01)
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More Files
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Specification
Product Description
Rabbit polyclonal antibody raised against a full-length human CD209 protein.
Immunogen
CD209 (NP_066978.1, 1 a.a. ~ 404 a.a) full-length human protein.
Sequence
MSDSKEPRLQQLGLLEEEQLRGLGFRQTRGYKSLAGCLGHGPLVLQLLSFTLLAGLLVQVSKVPSSISQEQSRQDAIYQNLTQLKAAVGELSEKSKLQEIYQELTQLKAAVGELPEKSKLQEIYQELTRLKAAVGELPEKSKLQEIYQELTWLKAAVGELPEKSKMQEIYQELTRLKAAVGELPEKSKQQEIYQELTRLKAAVGELPEKSKQQEIYQELTRLKAAVGELPEKSKQQEIYQELTQLKAAVERLCHPCPWEWTFFQGNCYFMSNSQRNWHDSITACKEVGAQLVVIKSAEEQNFLQLQSSRSNRFTWMGLSDLNQEGTWQWVDGSPLLPSFKQYWNRGEPNNVGEEDCAEFSGNGWNDDKCNLAKFWICKKSAASCSRDEEQFLSPAPATPNPPPA
Host
Rabbit
Reactivity
Human, Mouse
Interspecies Antigen Sequence
Mouse (66); Rat (62)
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
No additive
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Tissue lysate)
CD209 MaxPab rabbit polyclonal antibody. Western Blot analysis of CD209 expression in mouse liver.Western Blot (Tissue lysate)
CD209 MaxPab rabbit polyclonal antibody. Western Blot analysis of CD209 expression in human liver.Western Blot (Transfected lysate)
Western Blot analysis of CD209 expression in transfected 293T cell line (H00030835-T02) by CD209 MaxPab polyclonal antibody.
Lane 1: CD209 transfected lysate(45.8 KDa).
Lane 2: Non-transfected lysate.
Immunoprecipitation
Immunoprecipitation of CD209 transfected lysate using anti-CD209 MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead, and immunoblotted with CD209 purified MaxPab mouse polyclonal antibody (B01P) (H00030835-B01P). -
Gene Info — CD209
Entrez GeneID
30835GeneBank Accession#
NM_021155Protein Accession#
NP_066978.1Gene Name
CD209
Gene Alias
CDSIGN, CLEC4L, DC-SIGN, DC-SIGN1, MGC129965
Gene Description
CD209 molecule
Gene Ontology
HyperlinkGene Summary
This gene encodes a transmembrane receptor and is often referred to as DC-SIGN because of its expression on the surface of dendritic cells and macrophages. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are rare but have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 10332; often referred to as L-SIGN). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants
Other Designations
C-type lectin domain family 4, member L|CD209 antigen|Dendritic cell-specific intracellular adhesion molecules (ICAM)-3 grabbing non-integrin
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Interactome
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Disease
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