Western blot analysis of KCNIP2 over-expressed 293 cell line, cotransfected with KCNIP2 Validated Chimera RNAi ( Cat # H00030819-R01V ) (Lane 2) or non-transfected control (Lane 1). Blot probed with KCNIP2 monoclonal antibody (M01), clone 3E7 (Cat # H00030819-M01 ). GAPDH ( 36.1 kDa ) used as specificity and loading control.
This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belongs to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified from this gene. [provided by RefSeq
A-type potassium channel modulatory protein 2,Kv channel-interacting protein 2,OTTHUMP00000020332,OTTHUMP00000020333,OTTHUMP00000020336,OTTHUMP00000020337,OTTHUMP00000020339,OTTHUMP00000020340,cardiac voltage gated potassium channel modulatory subunit,pot