Immunoprecipitation of EFEMP2 transfected lysate using anti-EFEMP2 MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead (U0007), and immunoblotted with EFEMP2 purified MaxPab mouse polyclonal antibody (B01P) (H00030008-B01P).
A large number of extracellular matrix proteins have been found to contain variations of the epidermal growth factor (EGF) domain and have been implicated in functions as diverse as blood coagulation, activation of complement and determination of cell fate during development. The protein encoded by this gene contains four EGF2 domains and six calcium-binding EGF2 domains. This gene is necessary for elastic fiber formation and connective tissue development. Defects in this gene are cause of an autosomal recessive cutis laxa syndrome. [provided by RefSeq
fibulin 4,fibulin-like extracellular matrix protein,mutant p53 binding protein 1