PILRA (Human) Recombinant Protein (P01)
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More Files
- More Functions
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Specification
Product Description
Human PILRA full-length ORF ( AAH17812, 1 a.a. - 226 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MGRPLLLPLLPLLLPPAFLQPSGSTGSGPSYLYGVTQPKHLSASMGGSVEIPFSFYYPWELATAPDVRISWRRGHFHGQSFYSTRPPSIHKDYVNRLFLNWTEGQKSGFLRISNLQKQDQSVYFCRVELDTRSSGRQQWQSIEGTKLSITQGQQRTKATTPAREPFQNTEEPYENIRNEGQNTDPKLNPKLHLTQSTSQPPSPQEPPERDPVLCLKGLTNGQPSQD
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
50.6
Interspecies Antigen Sequence
Mouse (44)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — PILRA
Entrez GeneID
29992GeneBank Accession#
BC017812Protein Accession#
AAH17812Gene Name
PILRA
Gene Alias
FDF03
Gene Description
paired immunoglobin-like type 2 receptor alpha
Omim ID
605341Gene Ontology
HyperlinkGene Summary
Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This particular gene encodes the ITIM-bearing member of the receptor pair, which functions in the inhibitory role. Alternative splicing has been observed at this locus and three variants, each encoding a distinct isoform, are described. [provided by RefSeq
Other Designations
cell surface receptor FDF03|inhibitory receptor PILRalpha|paired immunoglobin-like receptor alpha|paired immunoglobulin-like receptor alpha|paired immunoglobulin-like type 2 receptor alpha
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Interactome
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