PILRA monoclonal antibody (M01), clone 3C2
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More Files
- More Functions
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Specification
Product Description
Mouse monoclonal antibody raised against a full length recombinant PILRA.
Immunogen
PILRA (AAH17812, 1 a.a. ~ 226 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
MGRPLLLPLLPLLLPPAFLQPSGSTGSGPSYLYGVTQPKHLSASMGGSVEIPFSFYYPWELATAPDVRISWRRGHFHGQSFYSTRPPSIHKDYVNRLFLNWTEGQKSGFLRISNLQKQDQSVYFCRVELDTRSSGRQQWQSIEGTKLSITQGQQRTKATTPAREPFQNTEEPYENIRNEGQNTDPKLNPKLHLTQSTSQPPSPQEPPERDPVLCLKGLTNGQPSQD
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (44)
Isotype
IgG1 kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (50.6 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Cell lysate)
PILRA monoclonal antibody (M01), clone 3C2 Western Blot analysis of PILRA expression in Hela S3 NE ( Cat # L013V3 ).Western Blot (Recombinant protein)
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged PILRA is approximately 3ng/ml as a capture antibody.ELISA
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Gene Info — PILRA
Entrez GeneID
29992GeneBank Accession#
BC017812Protein Accession#
AAH17812Gene Name
PILRA
Gene Alias
FDF03
Gene Description
paired immunoglobin-like type 2 receptor alpha
Omim ID
605341Gene Ontology
HyperlinkGene Summary
Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This particular gene encodes the ITIM-bearing member of the receptor pair, which functions in the inhibitory role. Alternative splicing has been observed at this locus and three variants, each encoding a distinct isoform, are described. [provided by RefSeq
Other Designations
cell surface receptor FDF03|inhibitory receptor PILRalpha|paired immunoglobin-like receptor alpha|paired immunoglobulin-like receptor alpha|paired immunoglobulin-like type 2 receptor alpha
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Interactome
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