Products

Western Blot

Entrez GeneID

GeneBank Accession#

Protein Accession#

Gene Name

A1CF

Gene Alias

ACF, ACF64, ACF65, APOBEC1CF, ASP, MGC163391, RP11-564C4.2

Gene Description

APOBEC1 complementation factor

Gene Ontology

Gene Summary

Mammalian apolipoprotein B mRNA undergoes site-specific C to U deamination, which is mediated by a multi-component enzyme complex containing a minimal core composed of APOBEC-1 and a complementation factor encoded by this gene. The gene product has three non-identical RNA recognition motifs and belongs to the hnRNP R family of RNA-binding proteins. It has been proposed that this complementation factor functions as an RNA-binding subunit and docks APOBEC-1 to deaminate the upstream cytidine. Studies suggest that the protein may also be involved in other RNA editing or RNA processing events. Alternative splicing occurs at this locus and three full-length transcript variants, encoding three distinct isoforms, have been described. Additional splicing has been observed but the full-length nature of these variants has not been determined. [provided by RefSeq

Other Designations

APOBEC-1 stimulating protein|OTTHUMP00000019611|OTTHUMP00000019612|OTTHUMP00000019614|OTTHUMP00000019615|OTTHUMP00000061209|apo-B RNA editing protein|apobec-1 complementation factor|apobec-1 complementation factor (ACF) (ASP)