LASS2 monoclonal antibody (M01A), clone 1A6
* The price is valid only in USA. Please select country.
-
More Files
- More Functions
-
Specification
Product Description
Mouse monoclonal antibody raised against a full-length recombinant LASS2.
Immunogen
LASS2 (AAH01357, 1 a.a. ~ 380 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
MLQTLYDYFWWERLWLPVNLTWADLEDRDGRVYAKASDLYITLPLALLFLIVRYFFELYVATPLAALLNIKEKTRLRAPPNATLEHFYLTSGKQPKQVEVELLSRQSGLSGRQVERWFRRRRNQDRPSLLKKFREASWRFTFYLIAFIAGMAVIVDKPWFYDMKKVWEGYPIQSTIPSQYWYYMIELSFYWSLLFSIASDVKRKDFKEQIIHHVATIILISFSWFANYIRAGTLIMALHDSSDYLLESAKMFNYAGWKNTCNNIFIVFAIVFIITRLVILPFWILHCTLVYPLELYPAFFGYYFFNSMMGVLQLLHIFWAYLILRMAHKFITGKLVEDERSDREETESSEGEEAAAGGGAKSRPLANGHPILNNNHRKND
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (92); Rat (92)
Isotype
IgM Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (67.32 KDa) .
Storage Buffer
In ascites fluid
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
-
Applications
Western Blot (Recombinant protein)
ELISA
-
Gene Info — LASS2
Entrez GeneID
29956GeneBank Accession#
BC001357Protein Accession#
AAH01357Gene Name
LASS2
Gene Alias
CerS2, FLJ10243, L3, MGC987, SP260, TMSG1
Gene Description
LAG1 homolog, ceramide synthase 2
Omim ID
606920Gene Ontology
HyperlinkGene Summary
This gene encodes a protein that has sequence similarity to yeast longevity assurance gene 1. Mutation or overexpression of the related gene in yeast has been shown to alter yeast lifespan. The human protein may play a role in the regulation of cell growth. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq
Other Designations
LAG1 longevity assurance 2|OTTHUMP00000033028|ceramide synthase 2|longevity assurance (LAG1, S. cerevisiae) homolog 2|tumor metastasis-suppressor
-
Interactome
-
Disease
-
Publication Reference
-
Endoplasmic reticulum stress and mitochondrial dysfunction during aging: Role of sphingolipids.
Qun Chen, Anna Kovilakath, Jeremy Allegood, Jeremy Thompson, Ying Hu, L Ashley Cowart, Edward J Lesnefsky.
Biochimica et Biophysica Acta. Molecular and Cell Biology of Lipids 2023 Oct; 1868(10):159366.
Application:WB, Mouse, Heart.
-
Loss of ceramide synthase 2 activity, necessary for myelin biosynthesis, precedes tau pathology in the cortical pathogenesis of Alzheimer's Disease.
Couttas TA, Kain N, Suchowerska AK, Quek L, Turner N, Fath T, Garner B, Don AS.
Neurobiology of Aging 2016 Apr; 43:89.
Application:WB-Ti, Human, Human brain.
-
siRNA-mediated down-regulation of ceramide synthase 1 leads to apoptotic resistance in human head and neck squamous carcinoma cells after photodynamic therapy.
Separovic D, Breen P, Joseph N, Bielawski J, Pierce JS, VAN Buren E, Gudz TI.
Anticancer research 2012 Jul; 32(7):2479.
Application:WB-Tr, Human, UM-SCC-22A cells.
-
Ceramide synthase 6 knockdown suppresses apoptosis after photodynamic therapy in human head and neck squamous carcinoma cells.
Separovic D, Breen P, Joseph N, Bielawski J, Pierce JS, VAN Buren E, Gudz TI.
Anticancer Research 2012 Mar; 32(3):753.
Application:WB-Ce, Human, Treated UM-SCC-22A.
-
Endoplasmic reticulum stress and mitochondrial dysfunction during aging: Role of sphingolipids.
- +1-909-264-1399
+1-909-992-0619
Toll Free : +1-877-853-6098 - +1-909-992-3401
- sales@abnova.com