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BLNK rabbit monoclonal antibody

  • Catalog # : H00029760-K
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  • Specification
  • Product Description:
  • Rabbit monoclonal antibody raised against a human BLNK peptide using ARM Technology.
  • Immunogen:
  • A synthetic peptide of human BLNK is used for rabbit immunization.
    Customer or Abnova will decide on the preferred peptide sequence.
  • Host:
  • Rabbit
  • Reactivity:
  • Human
  • Purification:
  • Protein A
  • Isotype:
  • IgG
  • Quality Control Testing:
  • Antibody reactive against human BLNK peptide by ELISA and mammalian transfected lysate by Western Blot.
  • Storage Buffer:
  • In 1x PBS, pH 7.4
  • Storage Instruction:
  • Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
  • Note:
  • 1. Customer may provide cell or tissue lysate for antibody screening.
    2. Rabbit monoclonal antibody generated by ARM technology is amenable to antibody engineering including F(ab)2, IgG, scFv and different Fc and non-Fc conjugates per customer request.
  • Library Construction:
  • Non-fusion antibody library from rabbit spleen (ARM Technology).
  • Expression:
  • Overexpression vector and transfection into 293H cell line.
  • Deliverable:
  • Up to three rabbit IgG clones of 1 mg each will be delivered to customer.
  • Applications
  • ELISA
  • Application Image
  • Western Blot (Transfected lysate)
  • ELISA
  • Gene Information
  • GeneBank Accession#:
  • BLNK
  • Gene Name:
  • BLNK
  • Gene Alias:
  • BASH,BLNK-S,LY57,MGC111051,SLP-65,SLP65
  • Gene Description:
  • B-cell linker
  • Gene Summary:
  • This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
  • Other Designations:
  • B cell linker protein,B-cell adapter containing a SH2 domain protein,B-cell adapter containing a Src homology 2 domain protein,OTTHUMP00000020167,Src homology 2 domain-containing leukocyte protein of 65 kDa
  • Interactome
  • Interactome
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