TBK1 293T Cell Transient Overexpression Lysate(Denatured)
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More Files
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SDS-PAGE Gel
TBK1 transfected lysate.
Western Blot
Lane 1: TBK1 transfected lysate ( 83.6 KDa)
Lane 2: Non-transfected lysate.
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-TBK1 full-length
Host
Human
Theoretical MW (kDa)
83.6
Interspecies Antigen Sequence
Mouse (94); Rat (94)
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-TBK1 antibody (H00029110-D01P)byWesternBlots.
SDS-PAGE Gel
TBK1 transfected lysate.
Western Blot
Lane 1: TBK1 transfected lysate ( 83.6 KDa)
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — TBK1
Entrez GeneID
29110GeneBank Accession#
NM_013254.2Protein Accession#
NP_037386.1Gene Name
TBK1
Gene Alias
FLJ11330, NAK, T2K
Gene Description
TANK-binding kinase 1
Omim ID
604834Gene Ontology
HyperlinkGene Summary
The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors. For example, the protein can form a complex with the IKB protein TANK and TRAF2 and release the NFKB inhibition caused by TANK. [provided by RefSeq
Other Designations
NF-kB-activating kinase
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Interactome
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Pathway
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Disease
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