RABGEF1 rabbit monoclonal antibody
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Specification
Product Description
Rabbit monoclonal antibody raised against a human RABGEF1 peptide using ARM Technology.
Immunogen
A synthetic peptide of human RABGEF1 is used for rabbit immunization.
Customer or Abnova will decide on the preferred peptide sequence.Host
Rabbit
Library Construction
Non-fusion antibody library from rabbit spleen (ARM Technology).
Expression
Overexpression vector and transfection into 293H cell line.
Reactivity
Human
Purification
Protein A
Isotype
IgG
Quality Control Testing
Antibody reactive against human RABGEF1 peptide by ELISA and mammalian transfected lysate by Western Blot.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Deliverable
Up to three rabbit IgG clones of 100 ug each will be delivered to customer.
Note
1. Customer may provide cell or tissue lysate for antibody screening.
2. Rabbit monoclonal antibody generated by ARM technology is amenable to antibody engineering including F(ab)2, IgG, scFv and different Fc and non-Fc conjugates per customer request. -
Applications
Western Blot (Transfected lysate)
ELISA
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Gene Info — RABGEF1
Entrez GeneID
27342GeneBank Accession#
RABGEF1Gene Name
RABGEF1
Gene Alias
FLJ32302, RABEX5, rabex-5
Gene Description
RAB guanine nucleotide exchange factor (GEF) 1
Omim ID
609700Gene Ontology
HyperlinkGene Summary
RABGEF1 forms a complex with rabaptin-5 (RABPT5; MIM 603616) that is required for endocytic membrane fusion, and it serves as a specific guanine nucleotide exchange factor for RAB5 (RAB5A; MIM 179512) (Horiuchi et al., 1997 [PubMed 9323142]).[supplied by OMIM
Other Designations
Rab5 GDP/GTP exchange factor
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Interactome
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Disease
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