APEX2 293T Cell Transient Overexpression Lysate(Denatured)
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More Files
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SDS-PAGE Gel
APEX2 transfected lysate.
Western Blot
Lane 1: APEX2 transfected lysate ( 57.09 KDa)
Lane 2: Non-transfected lysate.
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-APEX2 full-length
Host
Human
Theoretical MW (kDa)
57.09
Interspecies Antigen Sequence
Mouse (79); Rat (79)
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-APEX2 antibody (H00027301-B01) by Western Blots.
SDS-PAGE Gel
APEX2 transfected lysate.
Western Blot
Lane 1: APEX2 transfected lysate ( 57.09 KDa)
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — APEX2
Entrez GeneID
27301GeneBank Accession#
NM_014481.2Protein Accession#
NP_055296.2Gene Name
APEX2
Gene Alias
APE2, APEXL2, XTH2
Gene Description
APEX nuclease (apurinic/apyrimidinic endonuclease) 2
Gene Ontology
HyperlinkGene Summary
Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes a protein shown to have a weak class II AP endonuclease activity. Most of the encoded protein is located in the nucleus but some is also present in mitochondria. This protein may play an important role in both nuclear and mitochondrial base excision repair (BER). [provided by RefSeq
Other Designations
APEX nuclease-like 2|OTTHUMP00000023390|OTTHUMP00000061908|apurinic/apyrimidinic endonuclease 2|apurinic/apyrimidinic endonuclease-like 2
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Interactome
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Pathway
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Disease
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