APEX2 rabbit monoclonal antibody
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Specification
Product Description
Rabbit monoclonal antibody raised against a human APEX2 peptide using ARM Technology.
Immunogen
A synthetic peptide of human APEX2 is used for rabbit immunization.
Customer or Abnova will decide on the preferred peptide sequence.Host
Rabbit
Library Construction
Non-fusion antibody library from rabbit spleen (ARM Technology).
Expression
Overexpression vector and transfection into 293H cell line.
Reactivity
Human
Purification
Protein A
Isotype
IgG
Quality Control Testing
Antibody reactive against human APEX2 peptide by ELISA and mammalian transfected lysate by Western Blot.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Deliverable
Up to three rabbit IgG clones of 100 ug each will be delivered to customer.
Note
1. Customer may provide cell or tissue lysate for antibody screening.
2. Rabbit monoclonal antibody generated by ARM technology is amenable to antibody engineering including F(ab)2, IgG, scFv and different Fc and non-Fc conjugates per customer request. -
Applications
Western Blot (Transfected lysate)
ELISA
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Gene Info — APEX2
Entrez GeneID
27301GeneBank Accession#
APEX2Gene Name
APEX2
Gene Alias
APE2, APEXL2, XTH2
Gene Description
APEX nuclease (apurinic/apyrimidinic endonuclease) 2
Gene Ontology
HyperlinkGene Summary
Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes a protein shown to have a weak class II AP endonuclease activity. Most of the encoded protein is located in the nucleus but some is also present in mitochondria. This protein may play an important role in both nuclear and mitochondrial base excision repair (BER). [provided by RefSeq
Other Designations
APEX nuclease-like 2|OTTHUMP00000023390|OTTHUMP00000061908|apurinic/apyrimidinic endonuclease 2|apurinic/apyrimidinic endonuclease-like 2
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